Suspected acute meningitis
Recommended: No imaging before LP if no contraindications; otherwise CT Head first is an acceptable imaging study for suspected acute meningitis. Image first if focal deficit, papilledema, immunocompromised, recent seizure, or altered mental status.
Recommended study
No imaging before LP if no contraindications; otherwise CT Head first
Image first if focal deficit, papilledema, immunocompromised, recent seizure, or altered mental status. Do not delay antibiotics.
If the default doesn't apply
Complication suspected (cerebritis, abscess, ventriculitis)
MRI
MRI Brain with and without contrast
IV contrast
Watch-outs
Empiric antibiotics first
IDSA guideline: antibiotics within 60 minutes of suspected bacterial meningitis — never delay for imaging or LP.
Coagulopathy or thrombocytopenia
Correct before LP; platelet count generally ≥ 50K for safe LP.
Pearls
- Classic CSF profile: bacterial (low glucose, high protein, neutrophil predominance), viral (normal glucose, high lymphs), fungal/TB (low glucose, high lymphs).
- Add dexamethasone with first dose of antibiotics in suspected pneumococcal meningitis.
- Image when LP is delayed for any reason or focal neuro signs are present.